Christian Czech Selected Research

RG7800

1/2019

The oral splicing modifier RG7800 increases full length survival of motor neuron 2 mRNA and survival of motor neuron protein: Results from trials in healthy adults and patients with spinal muscular atrophy.

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Christian Czech Research Topics

Disease

23	Alzheimer Disease (Alzheimer's Disease) 08/2017 - 07/2002
6	Spinal Muscular Atrophy (Progressive Muscular Atrophy) 01/2021 - 01/2015
5	Amyloid Plaque 08/2017 - 04/2004
3	Parkinson Disease (Parkinson's Disease) 01/2021 - 01/2018
2	Huntington Disease (Huntington's Disease) 01/2019 - 12/2018
2	Fragile X Syndrome (Martin Bell Syndrome) 01/2018 - 01/2015
2	Atrophy 02/2015 - 08/2012
2	Neuroblastoma 11/2011 - 09/2005
2	Amyloidosis 09/2006 - 10/2003
2	Mitochondrial Diseases (Mitochondrial Disease) 11/2004 - 11/2003
1	Synucleinopathies 01/2021
1	Cough 01/2021
1	Parkinsonian Disorders (Parkinsonism) 01/2021
1	REM Sleep Behavior Disorder 01/2021
1	Inborn Genetic Diseases (Disease, Hereditary) 01/2020
1	Achondroplasia 01/2020
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2019
1	Muscular Atrophy (Muscle Atrophy) 01/2019
1	Hallucinations (Hallucination) 01/2018
1	Mental Disorders (Mental Disorder) 01/2018
1	Psychotic Disorders (Schizoaffective Disorder) 01/2018
1	Disease Progression 01/2017
1	Dementia (Dementias) 01/2017
1	Autism Spectrum Disorder 01/2017
1	Tooth Fractures 11/2015
1	Gliosis 09/2006
1	Amyloid angiopathy 09/2006
1	Cognitive Dysfunction 10/2003
1	Inflammation (Inflammations) 10/2003

Drug/Important Bio-Agent (IBA)

9	Amyloid (Amyloid Fibrils)IBA 02/2015 - 01/2003
7	Proteins (Proteins, Gene)FDA Link 01/2021 - 01/2003
7	Amyloid beta-PeptidesIBA 08/2017 - 07/2002
5	Biomarkers (Surrogate Marker)IBA 01/2021 - 01/2015
3	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 01/2008 - 10/2007
2	Peptide Hydrolases (Proteases)FDA Link 01/2021 - 01/2008
2	Neurotransmitter Agents (Neurotransmitter)IBA 01/2021 - 08/2012
2	Messenger RNA (mRNA)IBA 01/2019 - 01/2019
2	Pharmaceutical PreparationsIBA 01/2017 - 11/2011
2	PresenilinsIBA 02/2015 - 01/2005
2	Peptides (Polypeptides)IBA 01/2014 - 07/2002
2	Fluorescent Dyes (Fluorescent Probes)IBA 06/2013 - 12/2012
1	SynucleinsIBA 01/2021
1	alpha-SynucleinIBA 01/2021
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2021
1	Type 3 Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor 3)IBA 01/2020
1	RisdiplamIBA 01/2019
1	RG7800IBA 01/2019
1	Huntingtin ProteinIBA 01/2019
1	Neurofilament ProteinsIBA 12/2018
1	2- chloro- 4- (1- (4- fluorophenyl)- 2,5- dimethyl- 1H- imidazol- 4- ylethynyl)pyridineIBA 01/2018
1	Metabotropic Glutamate 5 ReceptorIBA 01/2018
1	Contrast MediaIBA 08/2017
1	Monoamine Oxidase (MAO)IBA 01/2017
1	Memantine (Namenda)FDA Link 01/2017
1	sembragilineIBA 01/2017
1	anti-NMDA receptor autoantibodyIBA 01/2017
1	Cholinesterase Inhibitors (Anticholinesterases)IBA 01/2017
1	Single-Domain AntibodiesIBA 12/2016
1	SynaptophysinIBA 02/2015
1	Fragile X Mental Retardation ProteinIBA 01/2015
1	Protein AggregatesIBA 01/2014
1	1,4- bis(4'- hydroxystyryl)- 2- methoxybenzeneIBA 01/2014
1	tau Proteins (tau Protein)IBA 01/2014
1	AcidsIBA 09/2013
1	Biological ProductsIBA 06/2013
1	Coloring Agents (Dyes)IBA 06/2013
1	2-styrylindoliumIBA 12/2012
1	PyrimidinesIBA 11/2012
1	PyrazinesIBA 11/2012
1	PyridazinesIBA 11/2012
1	Phosphotransferases (Kinase)IBA 11/2011
1	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 02/2010
1	Presenilin-2IBA 02/2010
1	Hydroxamic Acids (Hydroxamic Acid)IBA 01/2008
1	malonamideIBA 11/2007
1	N2- ((2S)- 2- (3,5- difluorophenyl)- 2- hydroxyethanoyl)- N1- ((7S)- 5- methyl- 6- oxo- 6,7- dihydro- 5H- dibenzo(b,d)azepin- 7- yl)- L- alaninamideIBA 11/2007
1	Apolipoprotein E4IBA 09/2005
1	Apolipoproteins E (ApoE)IBA 09/2005
1	Apolipoprotein E2IBA 09/2005
1	Cytochromes c (Cytochrome c)IBA 11/2003
1	Electron Transport Complex IV (Cytochrome c Oxidase)IBA 11/2003
1	Presenilin-1IBA 01/2003
1	Flavin-Adenine Dinucleotide (FAD)IBA 08/2002

Therapy/Procedure

2	Therapeutics 01/2017 - 10/2003
1	Wearable Electronic Devices 01/2021
1	Intravenous Administration 12/2016
1	Surgical Instruments (Clip) 11/2015